Locked nucleic acid as a novel class of therapeutic agents
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چکیده
منابع مشابه
Locked nucleic acid as a novel class of therapeutic agents.
Locked Nucleic Acid (LNA) is a nucleic acid analogue with unprecedented binding affinity and excellent specificity toward complementary RNA and DNA oligonucleotides. The remarkable properties of LNA have led to applications within various gene silencing strategies both in vitro and in vivo. In the present review, we highlight the uses of LNA for regulation of gene expression with emphasis on RN...
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Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides f...
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ژورنال
عنوان ژورنال: RNA Biology
سال: 2009
ISSN: 1547-6286,1555-8584
DOI: 10.4161/rna.6.3.8807